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Protein electrophoresis and immunofixation

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  • Protein electrophoresis and immunofixation
Created: 27/02/2024
Edited: 27/02/2024
Written by: Aoife Maguire

What is being analysed?

Protein electrophoresis and immunofixation are laboratory tests used to separate and identify proteins in the blood.

What does the result mean?

The result provides a pattern of proteins present in the blood serum or urine. It helps in diagnosing and monitoring various conditions, such as multiple myeloma, amyloidosis, and other protein-related disorders.

Why do the analysis?

Protein electrophoresis and immunofixation analysis are performed to detect abnormalities in protein levels or patterns, aiding in the diagnosis and management of various diseases.

When to do the analysis?

These tests are typically ordered when a patient presents symptoms suggestive of a protein-related disorder or when monitoring the progression of such conditions.

What sample is required?

Blood serum or urine samples are required for protein electrophoresis and immunofixation.

Is any type of prior preparation necessary?

Fasting may be required before the test, depending on the specific instructions provided by the healthcare provider.

How is it used?

Protein electrophoresis separates proteins based on their size and charge, while immunofixation further identifies specific types of proteins. Together, they provide a comprehensive analysis of protein abnormalities.

What are the normal values?

Protein Electrophoresis

Albumin: 55-65%

Alpha-1 globulin: 2-5%

Alpha-2 globulin: 7-12%

Beta globulin: 8-14%

Gamma globulin: 12-20%

What does it mean to have altered values?

High Levels: Elevated levels of specific proteins may indicate conditions such as multiple myeloma, Waldenström macroglobulinemia, or chronic inflammatory diseases.

Low Levels: Decreased levels of certain proteins may be seen in conditions like liver disease, malnutrition, or autoimmune disorders.

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